A Long-term Survivor after Congenital Acute Myeloid Leukemia with t(8 ; 16)(p11 ; p13).
نویسندگان
چکیده
The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.
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was not generated in this three-way translocation. Translocation t(8;18;16)(p11;q21;p13), another three-way translocation variant of t(8;16)(p11;p13) found in a 15month-old boy with AML M5b, also has a structure that could not generate CBP-MOZ but MOZ-CBP, while RTPCR was not performed in this case. Moreover, Murati et al. reported a 72-year-old man with AML M5a having a complex t(8;16)(p11;p13...
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عنوان ژورنال:
- Acta medica Okayama
دوره 70 1 شماره
صفحات -
تاریخ انتشار 2016